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WHAT IS “GMO”?

If you were around let’s say a hundred years ago, you would agree with me that the world today looks many times different from how it did then. Many men wore California hats and women wore heavy gowns but very interestingly, our crops and livestock had to wait so long or consume so many resources to produce a moderate amount of produce. For centuries before then, things had been that way however a hundred years past, harvest and nutritional impact increased geometrically. For a phenomenon that recorded little change over the centuries, a hundred years is so short to produce such drastic changes! What happened? Welcome to a world that is embracing the possibilities of GMOs! What are GMOs? From country to country, organization to organization, definitions differ in context and inclusions, however; I want you to have a definition that answers your curiosity and gives you a one size fits all meaning. GMOs can include anything whose gene had been altered even without human intervention but naturally.¹ Going by this definition, the scope of our discussion will become wider than what a blog post can handle. For easy understanding let us define GMOs as organisms especially crop plants and livestock that have undergone gene alterations under human manipulation. When gene alteration is mentioned, our minds travel to more sophisticated engineering and techniques such as cloning, artificial insemination, and gene manipulation done in labs. However, the European Union goes a bit broader to include less sophisticated methods such as selective breeding.² The Food and Agriculture Organization and the World Health Organization would not allow such broad definition, they opine that for an organism to be termed “organically modified”, its history of modification must not involve any natural recombination or mating.³ To be factual, even the world’s leading research organizations are still deciding what definition to accept for GMOs and Non-GMOs however you can take these definitions you read here for it and be certain what GMOs are. “ALTHOUGH GMOS HAVE BEEN ASSOCIATED WITH SOME PROBLEMS SUCH AS LOSS OF NUTRITION AND TOXICITY DUE TO UNSTABLE MOLECULES, YOU WILL BE INTERESTED TO FIND OUT HOW OUR LIVES CHANGED WITH THE ADVENT OF GMOS. ” How did it all begin? Although genetic modification is a new term, it is not without a precursor. As far back as 12,000 BC, people have been seeking ways to improve on the characteristics of living things⁴; crops and livestock to be precise. Techniques such as selective breeding were employed; two or more livestock of the same species with desirable qualities were mated together till they produce offsprings that bore desirable traits from both animals. This process is time-consuming and the probability of getting offspring with desired traits was minimal. In 1972, modern genetic modification got its first breakthrough when a man successfully performed an experiment that had never been done in recorded scientific history. The DNA of a monkey virus was merged with one from lambda virus via a DNA recombinant process and boom the world became aware of the possibility of DNAs from two species forming one molecule.⁵ The man was Paul Berg and that experiment paved way for several other genetic experiments that have shaped what we know today as GMOs. Although GMOs have been associated with some problems such as loss of nutrition and toxicity due to unstable molecules, you will be interested to find out how our lives changed with the advent of GMOs. How GMOs affected food production Many genetically modified organisms are crop plants and the aim revolves around three objectives; adaptability to environmental change, increased yield, and sustainability. Cash crops account for most of the genetically modified crop plants. In 2014, soybeans alone recorded half of all genetically modified crop plants planted.⁶ This is understandable because of its status as a cash crop. Though there are some experts raising concerns about the use of GMOs, their adoption into mainstream agriculture has been quite growing. ISAA reported that between 1996 and 2013, the total area of land where genetically modified crops were planted had increased by a factor of 100⁷ with most of these lands sited American countries then little other in Asia, Europe, and Africa. If you are a farmer, there are some persistent issues you’d face such as pest and disease invasion, heavy metal uptake from pesticides and herbicides. GMO encoders have such issues in mind when they engineer new varieties. For instance, most genetic coding for plants is gotten from Bacillus thuringiensis to produce vegetative proteins that are poisonous to insects. The farmer no longer has to purchase insecticides or deal with the environmental hazard of heavy metal accumulation in the soil. Other than pest and disease resistance, resistance to herbicides like glyphosate, and increased yield, genetic engineers have also encoded some food crops to produce more amounts of specific nutrients. If you consume genetically modified golden rice, for instance, you can be sure that you are consuming quantities of Vitamin A precursor at an amount higher than what is obtainable ordinary rice meal. The golden rice has three genes that are coded to biosynthesize beta-carotene which is a Vitamin A precursor.⁸ These plant modifications are not without certain concerns. Genetic codes of microbial origin used in the modification of these crops may become sources of antibiotic resistance in the long run. If this happens, certain medications we take to become well will prove ineffective.   The livestock industry hasn’t entertained many breakthroughs in genetic modification as its crop counterpart but some genetically engineered livestock species have not only been successful but have also been introduced into the market. The numbers are understandably few because coding the genes of mammals takes time, involves drudgery, and is cost-intensive. The process would involve implanting embryos in females with viral DNA, with the hope that the desired genetic traits would be formed within the reproductive cells of the offspring. This takes time because you would have to hold your horses till the offspring reaches the breeding stage before you

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HOW TO REVERSE AGE ON CELLULAR LEVEL?

HOW SELF HEALING PREVENTS AGAING? Since the dawn of time, mankind has sought the cure for death. Age after age, this idea has traveled through different paths of fantasy and insanity, through the fountains of youth and the elixirs of life, through the golden apples and the philosopher’s stones, and all paths have led to their culmination in the books of modern medicine. One cure, however, that still escapes all the collective knowledge of the entire human history, is the cure to the disease known as aging. But that might actually be changing soon… The basic structural and functional unit of the human body is the microscopic entity called the cell. Every small change that takes place inside it at a micro level, manifests itself at the macro level in the entire body. The body gets healthier as the cells get healthier, and it starts to deteriorate as the cells begin to age. Vinay Kum describes cellular aging in his book on pathology as “the result of a progressive decline in cellular function and viability caused by genetic abnormalities and the accumulation of cellular and molecular damage due to the effects of exposure to exogenous influences.” You must be thinking that if it’s the aging of cells that causes the aging of the entire body, then if we can partially or completely stop the cells from aging, can we perhaps prolong our youth or even restore it well into our 50s and 60s? Well maybe. But to get there we must first understand what cellular aging really is. So let’s break it down. HOW DO CELLS AGE? Different mechanisms have been described in detail in the medical literature like DNA damage due to inflammatory free radicals, epigenetic changes, shortening of telomeres, deformation of proteins, etc. The effect of diet and nutrition in triggering some metabolic pathways has also been implicated in the process of aging. DNA DAMAGE The information for normal structure, function, and division of cells to produce their progeny is encoded in the form of a collection of nucleotide bases called DNA. Aging is directly related to our DNA. Interestingly, certain genes directly regulate aging, and mutations in such genes can result in premature aging, as occurs in Werner’s syndrome. Remember, any damage to DNA can result in effects on all the components of a cell. A healthy cell is constantly exposed to insults by free radicals which can be produced due to exogenous influence like UV rays or endogenously within the cells. Endogenous free radicals are produced in mitochondria during the process of oxygen consumption called cellular respiration. Their levels are kept in check by anti-oxidative mechanisms. The efficacy of these mechanisms decreases as the cells age, leading to the accumulation of free radicals which damage the DNA. Since these free radicals originate in the mitochondria, mitochondrial DNA is especially prone to getting injured. “LIFESTYLE CHANGES IN OUR DIETS AND HABITS, AND EVEN IN THE WAY WE BREATHE CAN SET UP STALWART WALLS OF DEFENSE AGAINST SUCH INSULTS TO OUR DNA AND OUR CELLS, AND THAT IS EXACTLY WHAT WE PRACTICE HERE AT HOLISTICLIVEYOUNGER.” There exist certain mechanisms in our body that are responsible for DNA repair. With age, the efficacy of these repair mechanisms decreases. This causes the DNA to go through changes at certain points which we call mutations. An aged cell with such mutations can simply lead to cell death, or worse, to cancer Another mechanism of note is explained by the Antagonistic pleiotropy theory which describes the evolutionary aspect of aging. Pleiotropic genes encode opposing traits. Their favorable effects manifest early in life but they become harmful in later stages of life. By way of natural selection, such genes are selected from the gene pool owing to their beneficial effects in early life; when most people reproduce; which overrules their negative effects in the later stages of life. This is because the survival of the species is naturally more important to us than the survival of individuals, even if it comes at the expense of decreased longevity.⁴ But that doesn’t mean all is lost. Lifestyle changes in our diets and habits, and even in the way we breathe can set up stalwart walls of defense against such insults to our DNA and our cells, and that is exactly what we practice here at HolisticLiveYounger. SHORTENING OF TELOMERES Telomeres are short segments of DNA at the ends of chromosomes that protect them from degradation and ensure their complete replication. These segments get shortened each time a cell replicates and that eventually results in cessation of replication.² Our bodies have mechanisms to get rid of the aged cells. Continuous cellular replication allows newer cells to take the place of older ones. There is a limit, however, to the number of times a cell can divide, and once that limit is reached, the cells enter a phase called cellular senescence.⁵ These cells continue to wear off with time and, without getting replaced, eventually meet death. There is an enzyme, however, that can prevent this. It’s called telomerase and its job is to maintain the length of telomeres.⁶ It occurs naturally in many stem cells of our body as well as in cancer cells. That is one of the reasons why cancer cells tend to keep on replicating. Most of the cells in our body however lack this enzyme which is why the telomeres on their chromosomes keep on shortening. It may come as a surprise to you but merely changing what we eat, has been proven to be effective in prolonging our telomeres.¹ That opens a way to augment the health and replicative capacity of our cells in a realistic manner. ¹https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316700/#:~:text=Telomere%20length%20is%20positively%20associated,28%2C33%2C34%5D DIET AND NUTRITION Paradoxical though it may seem, eating less increases your chances of living longer and healthier lives. The nutrient-sensing mechanisms in our body are governed by certain hormones or substances. Among these are Insulin and Insulin-like growth factor 1.⁷ Researches in mice models indicate that aging is directly correlated to the

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